Marinate the Chicken: In a bowl, combine the buttermilk, garlic powder, onion powder, paprika, salt, and pepper. Add the chicken breasts and ensure they are fully coated. Cover and refrigerate for at least 1 hour, or overnight for best results.

Prepare the Breading: Once marinated, remove the chicken from the buttermilk and let excess drip off. Dredge each breast in panko breadcrumbs, pressing gently to adhere the crumbs.

Preheat the Air Fryer: Preheat the air fryer to 380°F (193°C) for about 5 minutes.

Cook the Chicken: Spray the air fryer basket with cooking spray. Arrange the breaded chicken breasts in a single layer, making sure they don’t overlap. Spray the tops lightly with cooking spray.

Air Fry: Cook the chicken for 12-15 minutes, flipping halfway through, until the internal temperature reaches 165°F (75°C) and the outside is golden brown and crispy.

Serve: Allow the chicken to rest for a few minutes before slicing. Serve hot with your favorite sides.