Prepare the Sauce: In a small bowl, combine mayonnaise, ketchup, mustard, pickle relish, paprika, and season with salt and pepper. Mix well and set aside.

Make the Patties: In a large bowl, combine ground beef, garlic powder, onion powder, salt, and pepper. Form into 4 equal patties, making a slight indentation in the center of each to prevent puffing during grilling.

Preheat the Grill: Heat your grill to medium-high heat. Ensure the grates are clean and oiled to prevent sticking.

Grill the Patties: Place the patties on the grill and cook for about 4-5 minutes per side, or until they reach your desired doneness. Use a meat thermometer for accuracy (160°F for medium).

Toast the Buns: In the last minute of cooking, place the burger buns cut side down on the grill to toast them lightly. This is a perfect time to add cheese to burgers.

Assemble the Burgers: Spread a generous amount of the homemade burger sauce on the bottom half of each bun. Top with the grilled patty and your choice of lettuce, tomato, and onion. Place the top bun over the toppings and serve immediately.